个人简介

施豪缘，中共党员，医学博士，具备生物信息学与基础医学交叉学科研究背景。2019 年本科毕业于福建医科大学生物信息学专业，硕士、博士阶段先后在福建医科大学与国家纳米科学中心开展科研工作，2023 年获博士学位，导师为胡志远教授。2024 年-2026 年于中国医学科学院肿瘤医院 / 国家癌症中心从事博士后研究，合作导师邢念增教授；曾获国家资助博士后研究人员计划资助。

研究领域

主要从事多组学与人工智能交叉研究，整合单细胞、空间转录组、蛋白质组、代谢组、医学影像及临床等多维数据，聚焦肿瘤发生发展、转移及治疗反应。重点开展单细胞算法开发、肿瘤微环境与细胞调控网络解析，以及基于液体活检的疾病早期诊断、预后分层和个体化疗效预测研究，探索人工智能方法在疾病机制研究与精准医学中的应用。

代表性成果

近五年共发表SCI论文16篇，其中以第一作者或通讯作者（含共同第一、共同通讯作者）发表13篇，相关成果发表于Cell Death & Disease、Theranostics、Oncogene、Small等国际学术期刊。

1.Shi, H.#, Chen, J.#, Wu, Z.#, Liu, D.-X., Zhou, J., Wu, X., Yang, A., Li, S., Tai, Y., Jiang, Z., Hu, Z., Zhang, M., Xu, X., Pan, L., & Wang, T. (2026). Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis. Cell Death & Disease, 17, 553.

2.Chen, J., Hao, Y., Feng, Y., Dai, Y.*, Shi, H.*, & Zhu, L.* (2026). Lactylation-mediated remodelling of the breast cancer microenvironment: single-cell multidimensional analysis and prognostic model construction. Frontiers in Immunology, 17, 1747043.

3.Guo, H.#, Shi, H.#, Feng, Y., Guo, Y., Zhang, X., Wang, P., Hu, C., Mei, H., Li, Y., & Zhu, J. (2026). A study for potential rapid discrimination of smokeless powders by near-infrared spectroscopy and chemometric modeling methods for forensic application. Scientific Reports, 16, 15981.

4.Feng, Y., Zhang, X., Wang, G., Yang, F., Li, R., Yin, L., Chen, D., Wang, W., Wang, M., Hu, Z., Sh, Y.*, & Xing, N.* (2025). Comprehensive integrated analysis reveals the spatiotemporal microevolution of cancer cells in patients with bone-metastatic prostate cancer. Biomedicines, 13(4), 909.

5.Wang, A.#, Zeng, P.#, Ma, T.#, Shi, H.#, Li, R., Xu, H., Feng, Y., Liu, Q., Wang, M., Chen, T., Hu, Z., Wang, R., Zhou, Y., & Hao, X. (2025). Establishment of a new method for detection of TROP2-positive circulating tumor cells in breast cancer. BMC Cancer, 25(1), 1797.

6.Yin, L., Yang, F., Wang, W., Zhang, L., Cao, Z., Shi, H., Pan, K., Wu, L., Xiao, H., & Xing, N. (2025). PSMA-targeted nanoparticles with PI3K/mTOR dual inhibitor downregulate P-glycoprotein and inactivate myeloid-derived suppressor cells for enhanced chemotherapy and immunotherapy in prostate cancer. Advanced Materials, 37(26), e2415322.

7.Chen, J.#, Sh, Y.#, Dong, D., et al. (2025). Development of a prognostic risk stratification model for HER2-positive breast cancer brain metastasis and its implications in guiding treatment decisions. Scientific Reports, 15, 22623.

8.Jiang, S., Cai, G., Yang, Z., Shi, H., Zeng, H., Ye, Q., Hu, Z., & Wang, Z. (2024). Biomimetic nanovesicles as a dual gene delivery system for the synergistic gene therapy of Alzheimer's disease. ACS Nano, 18(18), 11753-11768.

9.Zhang, X.#,*, Sh, Y.#,*, Dong, J., Chen, Z., & Hong, F. (2023). The landscape of abnormal pathway activation confers COVID-19 patients' molecular sequelae earlier than clinical phenotype. Theranostics, 13(10), 3451-3466.

10.Yang, Z.#, Shi, H.#, Cai, G.#, Jiang, S., Hu, Z.*, & Wang, Z.* (2023). A reactive oxygen species-responsive targeted nanoscavenger to promote mitophagy for the treatment of Alzheimer's disease. Small, 19(42), e2302284.

11.Sh, Y.#, Dong, J.#, Chen, Z.#, Yuan, M.*, Lyu, L.*, & Zhang, X.* (2023). Active regression model for clinical grading of COVID-19. Frontiers in Immunology, 14, 1141996.

12.Zhou, Y.#, Zhou, J.#, Hao, X.#, Shi, H.#, Li, X., Wang, A., Hu, Z.*, Yang, Y.*, Jiang, Z.*, & Wang, T.* (2023). Efficacy relevance of PD-L1 expression on circulating tumor cells in metastatic breast cancer patients treated with anti-PD-1 immunotherapy. Breast Cancer Research and Treatment, 200(2), 281-291.

13.Sh, Y.#,*, Zhang, X.#,*, Yang, Z.#, Dong, J., Wang, Y., Zhou, Y., Li, X., Guo, C., & Hu, Z.* (2022). CaSee: A lightning transfer-learning model directly used to discriminate cancer/normal cells from scRNA-seq. Oncogene, 41(44), 4866-4876.

14.Zhou, Y., Zhou, J., Xiao, J., Wang, Y., Wang, H., Shi, H., Yue, C., Jia, F., Li, P., Hu, Z., Yang, Y., Jiang, Z., & Wang, T. (2022). Prognostic relevance of estrogen receptor status in circulating tumor cells in breast cancer patients treated with endocrine therapy. Frontiers in Oncology, 12, 866293.

15.Sh, Y.#, Liu, B.#, Zhang, J.#, Zhou, Y.#, Hu, Z.*, & Zhang, X.* (2021). Application of artificial intelligence modeling technology based on fluid biopsy to diagnose Alzheimer's disease. Frontiers in Aging Neuroscience, 13, 768229.

16.Zhang, J.#, Zhang, X.#, Sh, Y.#, Liu, B., & Hu, Z. (2021). Diagnostic AI modeling and pseudo time series profiling of AD and PD based on individualized serum proteome data. Frontiers in Bioinformatics, 1, 764497.