郑向东 特聘教授、博士生导师 E-mail：zxdlilon@163.com

个人简介

郑向东博士本科毕业于哈尔滨工业大学（2008年），2015年在清华大学医学院获理学博士学位。2015-2021年先后于清华大学医学院、美国哥伦比亚大学生物系从事博士后研究。2021-2026年就职于郑州大学医学前沿交叉学院，2026年加入北京中医药大学未来医学学院，主动健康方向负责人。

郑向东博士致力于代谢稳态与慢病衰老机制研究，聚焦微量元素、营养物质及代谢产物的转运和感知，整合表观遗传调控网络，解析中药活性成分靶向干预物质能量代谢紊乱、细胞衰老进程及代谢相关慢性疾病的分子作用机理，相关成果发表在Cell Insight (2024)、Nature Structural & Molecular Biology (2022,2020)、Molecular Cell (2019)、Nature Communications (2016)、PNAS (2014)等国际著名期刊。近年来，入选河南省高层次人才D类、教育部博士后海外引才专项〔回国 (来华) 工作〕、河南省中原英才计划（引才系列）青年项目，主持国家自然科学基金面上项目1项、河南省科技研发计划联合基金重点项目1项、中国博士后科学基金面上资助1项等，参编科普读物1本（副主编）、校级本科生教材1本，指导校级大学生创新创业训练计划项目2项并顺利结题。

研究领域

聚焦代谢稳态与中医药交叉前沿，围绕两大核心科学问题——糖脂代谢稳态与慢病发生关系的机制解析，以及中药与药食同源干预策略的开发与评估，建立以分子互作、结构生物学、多组学分析与人工智能为基础的多维交叉研究体系，形成从计算预测到实验确证，从结构阐释到系统验证，从机制解析到干预转化的闭环研究范式，为代谢性慢病防治与健康衰老提供中医药解决方案。主要研究方向包括：

1.代谢稳态维持与慢病衰老机制解析。聚焦糖脂代谢稳态如何维持、为何失衡、如何驱动慢病与衰老，从分子、细胞、器官到整体多层级阐明代谢性慢病（肥胖、2型糖尿病、脂肪肝、动脉粥样硬化、肿瘤等）的发生发展规律。

2.中药干预慢病衰老机制解析。聚焦中药（复方、经方、活性成分）防治代谢性慢病与延缓衰老的物质基础与作用机制，以现代生命科学语言阐释中药疗效的科学内涵。

3.药食同源活性物质作用机制解析。聚焦药食同源物质中功能活性成分的发现、机制阐明与应用评估，推动传统食养经验的现代化、标准化与精准化。

代表性成果

1.Qu, H., Zhen, Y., Xu, M., Huang, Y., Wang, Y., Ji, G., Zhang, Y., Li, H., Dong, Z.# & Zheng, X.# (2024). Structures of a sperm-specific sodium-hydrogen exchanger. Cell Insight, 3, 100177.

2.Hu, Z., Zheng, X. & Yang, J. (2023). Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel. Nat Commun, 14, 4284.

3.Guan, H., Wang, P., Zhang, P., Ruan, C., Ou, Y., Peng, B., Zheng, X., Lei, J., Li, B., Yan, C. & Li, H. (2023). Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature, 620, 669-675.

4.Zheng, X.*, Li, H.*, Hu, Z.*, Su, D. & Yang, J. (2022). Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel. Commun Biol, 5, 190.

5.Zheng, X., Hu, Z., Li, H. & Yang, J. (2022). Structure of the human cone photoreceptor cyclic nucleotide-gated channel. Nat Struct Mol Biol, 29, 40-46.

6.Zheng, X.*, Fu, Z.*, Su, D.*, Zhang, Y., Li, M., Pan, Y., Li, H., Li, S., Grassucci, R. A., Ren, Z., Hu, Z., Li, X., Zhou, M., Li, G., Frank, J. & Yang, J. (2020). Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat Struct Mol Biol, 27, 625-634.

7.Zhao, S., Cheng, L., Gao, Y., Zhang, B., Zheng, X., Wang, L., Li, P., Sun, Q. & Li, H. (2019). Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation. Cell Res, 29, 54-66.

8.Wang, L.*, Gao, Y.*, Zheng, X.*, Liu, C., Dong, S., Li, R., Zhang, G., Wei, Y., Qu, H., Li, Y., Allis, C. D., Li, G., Li, H. & Li, P. (2019). Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism. Mol Cell, 76, 646-659 e6.

9.Mariappan, A., Soni, K., Schorpp, K., Zhao, F., Minakar, A., Zheng, X., Mandad, S., Macheleidt, I., Ramani, A., Kubelka, T., Dawidowski, M., Golfmann, K., Wason, A., Yang, C., Simons, J., Schmalz, H. G., Hyman, A. A., Aneja, R., Ullrich, R., Urlaub, H., Odenthal, M., Buttner, R., Li, H., Sattler, M., Hadian, K. & Gopalakrishnan, J. (2019). Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. EMBO J, 38.

10.Liu, G.*, Zheng, X.*, Guan, H.*, Cao, Y., Qu, H., Kang, J., Ren, X., Lei, J., Dong, M. Q., Li, X. & Li, H. (2019). Architecture of Saccharomyces cerevisiae SAGA complex. Cell Discov, 5, 25.

11.Zheng, X.*, Ramani, A.*, Soni, K., Gottardo, M., Zheng, S., Ming Gooi, L., Li, W., Feng, S., Mariappan, A., Wason, A., Widlund, P., Pozniakovsky, A., Poser, I., Deng, H., Ou, G., Riparbelli, M., Giuliano, C., Hyman, A. A., Sattler, M., Gopalakrishnan, J. & Li, H. (2016). Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length. Nat Commun, 7, 11874.

12.Yang, S., Zheng, X., Lu, C., Li, G. M., Allis, C. D. & Li, H. (2016). Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase. Genes Dev, 30, 1611-6.

13.Li, N., Li, Y., Lv, J., Zheng, X., Wen, H., Shen, H., Zhu, G., Chen, T. Y., Dhar, S. S., Kan, P. Y., Wang, Z., Shiekhattar, R., Shi, X., Lan, F., Chen, K., Li, W., Li, H. & Lee, M. G. (2016). ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Mol Cell, 63, 470-84.

14.Wu, R., Yue, Y., Zheng, X. & Li, H. (2015). Molecular basis for histone N-terminal methylation by NRMT1. Genes Dev, 29, 2337-42.

15.Meng, Q., Liu, G., Liu, Y., Deng, X., Wang, W., Xu, K., Zheng, X., Zhang, D., Pang, H. & Chen, H. (2015). A broad protection provided by matrix protein 2 (M2) of avian influenza virus. Vaccine, 33, 3758-65.

16.Zheng, X.*, Gooi, L. M.*, Wason, A., Gabriel, E., Mehrjardi, N. Z., Yang, Q., Zhang, X., Debec, A., Basiri, M. L., Avidor-Reiss, T., Pozniakovsky, A., Poser, I., Saric, T., Hyman, A. A., Li, H. & Gopalakrishnan, J. (2014). Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis. Proc Natl Acad Sci U S A, 111, E354-63.

17.Zheng, X., Guo, J.*, Xu, L., Li, H., Zhang, D., Zhang, K., Sun, F., Wen, T., Liu, S. & Pang, H. (2011). Crystal structure of a novel esterase Rv0045c from Mycobacterium tuberculosis. PLoS One, 6, e20506.

18.Xu, L., Guo, J., Zheng, X., Wen, T., Sun, F., Liu, S. & Pang, H. (2010). Crystallization and preliminary X-ray analysis of a novel esterase Rv0045c from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun, 66, 1579-82.

19.Liu, Z., Zhou, Q., Mao, X., Zheng, X., Guo, J., Zhang, F., Wen, T. & Pang, H. (2010). Crystallization and preliminary X-ray analysis of cecropin B from Bombyx mori. Acta Crystallogr Sect F Struct Biol Cryst Commun, 66, 851-3.

20.Guo, J.*, Zheng, X.*, Xu, L., Liu, Z., Xu, K., Li, S., Wen, T., Liu, S. & Pang, H. (2010). Characterization of a novel esterase Rv0045c from Mycobacterium tuberculosis. PLoS One, 5.